一本一道久久a久久精品,免费国产成高清人在线视频,亚洲成av人片天堂网

鄭重說明:

您值得信賴的中藥成分及標準合作伙伴滿足您研發和工業化需求

產品關鍵詞：香草酸-4-β-D-葡萄糖苷 6-甲氧基山奈酚茯苓新酸B 去甲異波爾定

guanyuwomen關于德思特

聯系方式

服務熱線：

028-8500-3950

公司傳真：	028-85589956
公司郵箱：	sales@tcmlmt.com
公司網址：	www.hamilton.org.cn
公司地址：	四川省成都市溫江區海科路西段128號5棟

發表文獻展示

當前位置:首頁關于德思特 > 發表文獻展示 >

The Journal of Supercritical Fluids-26 August 2019 藤黃酸

時間：2020-09-03 瀏覽次數：分享到：

Solubility measurement and RESOLV-assisted nanonization of gambogic acid in supercritical carbon dioxide for cancer therapy
期刊名：The Journal of Supercritical Fluids
文獻編號：DOI 10.1016/j.supflu.2019.04.008
文獻地址：https://www.sciencedirect.com/science/article/pii/S0896844619300658?via%3Dihub
發表日期：26 August 2019

Abstract
Despite the captivating interest for its potential anticancer efficacy against multiple types of cancer and ability to overcome multidrug resistance, the practical application of gambogic acid (GA) has been hampered by its poor water solubility. Herein, the fabrication of nanosized GA particles (251.2 nm ± 85.6 nm) using eco-friendly supercritical fluid (SCF)-assisted rapid expansion of a supercritical solution into a liquid solvent (RESOLV) process was demonstrated. The equilibrium solubility of GA in supercritical carbon dioxide (SC−CO2) was initially determined at altered supercritical conditions (P: 10.0 MPa to 30.0 MPa, T: 308.15 K–328.15 K) and the obtained data points were then correlated using various density-based models including Méndez-Santiago and Teja, Bartle as well as Chrastil models. The solubility of GA in SC−CO2 was found to be between 1.63 × 10−6 and 22.62 × 10−6 in terms of GA mole fraction, and considerably good correlation agreement was obtained with all the applied models and being the lowest deviations obtained with the Méndez-Santiago and Teja model. Furthermore, the fabricated GA nanoparticles (NPs) through benign RESOLV technique, were systematically characterized. Subsequently, in vitro antiproliferation tests resulted in its augmented antitumor efficacy due to enhanced solubility of GA. Together, the results have suggested that the benign RESOLV process has successfully fabricated nanosuspensions of GA with enhanced bioavailability and antineoplastic efficacy and may have great potential in pharmaceutics.

gambogic acid was purchased from DeSiTe Biological Technology Co. Ltd. (Chengdu, China)

上一篇：Royal Society of Chemistry-12 Aug 2019 圣草次苷

下一篇：Molecules-23 July 2019 半齒澤蘭素

Afrormosine CAS:550-79-8 中藥對照品標準品

產品編碼：DA0040產品名稱：Afrormosine英文名:AfrormosineCAS登錄...

人妻少妇免费午夜无码区,久久爆乳AⅤ无码一区二区,日本精品久久久久影院日本,99精品66AV99精品